● Nature Cell Biology (IF 17.3) Chen et.al. (2025). Rpl12
is a conserved ribophagy receptor. [浙江大学易聪、邹炜团队，广州医科大学冯杜团队、国科大杭州高等研究院黄云鹏团队联合天津大学梅坤荣 rAAV9-RPL12-WT、rAAV9-RPL12 P3N-E21L 核糖体稳态]
● Nature Metabolism (IF 18.9). Zheng et.al. (2024). S-acylation of ATGL is required for lipid
droplet homoeostasis in hepatocytes. [浙江大学医学院附属第四医院Dante Neculai、刘伟团队联合加拿大多伦多大学Brian
Raught团队和加拿大戴尔豪斯大学Gregory
D. Fairn团队 脂肪代谢]
● Circulation，（IF 37.8）.Zhan JB .（2023）. Ago2 protects against diabetic cardiomyopathy via activating mitochondrial gene translation.［华中科技大学附属同济医院心血管内科，AAV9-cTNT-NLS-Ago2，AAV9-cTNT-NES-Ago2，AAV9-cTNT-COX8-Ago2，AAV9-cTNT-shRNA-Ago2，尾静脉注射，糖尿病］
●Metabolism，（IF 9.8）.Hu YT.（2023）. Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation.［北京大学医学部基础医学院、北京大学人民医院，AAV8-FPR1、AAV8-GFP，尾静脉注射，肝脂肪代谢］
● Nature Communications. (IF 17.694). Zhong et.al. (2023). Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice. [中山大学附属第六医院 AAV8-TAK1；AAV8-Vec；AAV8-Adipoq-Cre AAV过表达载体肥胖代谢]
● Acta Pharmaceutica Sinica B.（IF=14.5）.Tang WZ，et.al.（2023）.Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPARγ/FABP4 signaling in mice.［南方科技大学&南方科技大学第一附属医院 AAV-Rec2-CasRx-sgRNA-Kindlin-2 脂肪］
● Protein & Cell.（IF=15.328）.Maomao-Pu，et.al.（2023）.ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover .［浙江大学医学院 AAV9-ORP8-WT 、AAV9-ORP8-T54A/S65A、AAV9-ORP8-LIRs-6A 、AAV9- ORP5 脂滴自噬］
● Cell Death and Differentiation (IF=13.7) .Liu C, et.al. (2024). Foxk1 promotes bone formation through inducing aerobic glycolysis.［深圳市人民医院 AAV9-Osterix-Foxk1、AAV9-Osterix-GFP 骨形成］
● Cell Communication and Signaling (IF 8.2).Sun K, et.al. (2024). IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte damage in osteoarthritis.［华中科技大学同济医学院附属同济医院 AAV9-shZBP1、AAV9-shGFP 骨关节炎］
● Free Radical Biology and Medicine.（IF=8.101）.Kai Sun，et.al.（2023）.JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy.［华中科技大学同济医学院附属同济医院关节腔内注射AAV9-NCOA4 & AAV9-GFP骨关节炎治疗］
● Nature Metabolism (IF 18.9) Peng et.al. (2025). Cellular
Feimin enhances exercise performance by suppressing muscle thermogenesis. [清华大学王一国 AAV9-cFeimin；AAV9-cFeimin
112/128T/A；AAV9-cFeimin
112/128T/D；AAV9-cFeimin
124/140R/D；AAV9-shcFeimin 肌肉产热]
● Molecular Therapy (IF=12.4). Cataldi MP, et.al. (2023). Improved efficacy of FKRP AAV gene therapy by combination with ribitol treatment for LGMD2I.［Atrium Health卡罗来纳医疗中心 AAV9-MCK-FKRP 肌营养不良］
● Science Advances（IF=13.6）. Jia M, et.al. (2023). ULK1-mediatedmetabolic reprogramming regulates Vps34 lipid kinase activity by itslactylation.［华东理工大学 rAAV-Vps34WT、rAAV-Vps342KR、rAAV-Ctrl 骨骼肌稳态］
● Skeletal Muscle (IF=4.9).Witcher PC, et.al. (2023). Expression of Myomaker and Myomerger in myofbers causes muscle pathology.［辛辛那提儿童医院 AAV9-CMV-Myomerger 、AAV9-GFP 肌肉病理］
● Biomedicine & Pharmacotherapy（IF=7.5 ）.Wu Y, et.al. (2022). Endothelium-targeted delivery of PPARδ by adeno-associated virus serotype 1 ameliorates vascular injury induced by hindlimb ischemia in obese mice.［香港中文大学 AAV1-ICAM2-Ppard 、AAV1-control 糖尿病血管病变］
● JCI Insight (IF=8.0).Kwong JQ, et.al. (2018). The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle.［辛辛那提儿童医院 AAV9-Cre、 AAV9-GFP 骨骼肌代谢］
● Redox Biology，（IF 10.787）. Zhu Jian.（2023）. The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing Sirt3 .［海军军医大学第二附属医院（上海长征医院），AAV-USP11 & AAV-Ctrl，椎间盘内注射］
● Cell Reports.（IF=9.995）. Liu, et.al. (2022). Template-independent genome editing in the Pcdh15 av-3j mouse, a model of human DFNB23 nonsyndromic deafness.［清华大学 AAV2/9-mCherry&AAV2/9-m-3j-gRNA1 遗传性耳聋］
● Cell Reports Medicine (IF 14.3).Li CP, et.al. (2024). Lhx2 promotes axon regeneration of adult retinal ganglion cells and rescues neurodegeneration in mouse models of glaucoma.［中国科学院动物研究所、北京同仁医院 AAV2-CAG-PLAP、AAV2-CAG-CNTF 青光眼神经退行性病变］
● Cell Death and Disease，（IF 9）.Li Y.（2023）. TGR5 supresses cGAS/STING pathway by inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy.［南京医科大学附属无锡人民医院，AAV8-shTGR5，AAV8-vector，玻璃体内注射2μL，糖尿病视网膜病变］
● Antioxidants(IF7.675).ZhangF,et.al.(2023).Melatonin Alleviates Retinal Ischemia-Reperfusion Injury by Inhibiting p53–Mediated Ferroptosis.［中山大学中山眼科中心 AAV2-p53& AAV2-GFP 视网膜缺血再灌注］
● COMPUT STRUCT BIOTEC（IF 6.155）. Zhang J, et.al. (2023). PDGF-D-induced immunoproteasome activation and cell-cell interactions.［中山大学中山眼科中心&广医-广州生物院 AAV-VMD2-PDGF-D&AAV-GFP 脉络膜新生血管］
● International Journal of Biological Sciences. (IF=4.858). Wu, et.al. (2019). Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.［温州医科大学附属第二医院 AAV9-U6-shRNA (Prkaa1)-CMV-EGFP 随意皮瓣］
● Cell Communication and Signaling (IF 8.9). Chen Y, et.al. (2025). Inhibition of tubular epithelial cells ferroptosis alleviates renal interstitial fibrosis by reducing lipid hydroperoxides and TGF-β/Smad signaling.［华中科技大学同济医学院附属同济医院 AAV9-mGPX4 、AAV9-vector 肾间质纤维化］
● Free Radical Biology and Medicine (IF=7.1). Hu H, et.al. (2025). Dapagliflozin Attenuates Diabetes-Induced Podocyte Lipotoxicity via ERRα-Mediated Lipid Metabolism.［武汉大学人民医院 AAV-nphs1-shACOX1、AAV-nphs1-null 糖尿病肾病］
● Molecular Therapy (IF 12.1).Song Z, et.al. (2024). The novel potential therapeutic target PSMP/MSMP promotes acute kidney injury via CCR2.［北大基础医学院、北大第一医院 AAV9-hPSMP、AAV9-null 急性肾损伤］
● Metabolism Clinical and Experimental，（IF 9.8）. Zuo Fuwen.（2023）. CCDC92 deficiency ameliorates podocyte lipotoxicity in diabetic kidney disease.［山东大学基础医学院，AAV9-Nphs1-Ccdc92、AAV9-Nphs1-shAbca1，糖尿病肾病-肾实质内注射］
● Cell Death Discovery. (IF 7.0). Zhang et.al. (2023). Disruption of RCAN1.4 expression mediated by
YY1/HDAC2 modulates chronic renal allograft interstitial fibrosis. [南京医科大学第一附属医院 AAV慢病毒过表达载体 AAV9-RCAN1.4
LV-RCAN1.4、LV-YY1 肾脏]
● Life Sciences（IF=6.780）. Hu BC, et.al. (2023). Auto- and paracrine rewiring of NIX-mediated mitophagy by insulin-like growth factor-binding protein 7 in septic AKI escalates inflammation-coupling tubular damage.［浙江省人民医院AAV9-KSP1.3-miR30-sh.NIX &AAV9-sh.scr 脓毒性AKI］
● Nature Communications (IF=17.694). Yang Y, et.al. (2023). DNA-dependent protein kinase catalytic subunit (DNA-PKcs) drives chronic kidney disease progression in male mice.［南京医科大学附属儿童医院AAV8-U6-gRNA-DNA-PKcs；AAV8-U6-gRNA 慢性肾脏病］
● Molecular Therapy. （IF=12.910）. Ouyang X, et.al. (2022). A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating AKT/mTOR-autophagy pathway. ［广东人民医院 AAV9-sh-circ-ZNF609 & AAV9-ZNF609-250 & AAV9-sh-NC 急性肾损伤］
● Cytokine.(IF=3.926). Xu H, Wang Z. (2022). MicroRNA-23a-3p ameliorates acute kidney injury by targeting FKBP5 and NF-κB signaling in sepsis.［江西省人民医院 AAV2-miR-23a-3p 脓毒症急性肾损伤］
● Molecular Therapy. (IF=12.910) . Sung-Ah Hong, et.al.（2021）. In vivo gene editing via homology-independent targeted integration for adrenoleukodystrophy treatment. [延世大学AAV9-HITI & AAV9-SaCas9-sgRNA & AAV9-EGFP 肾上腺脑白质营养不良(ALD)]
● Acta Pharm Sin B. (IF=11.413). Jing X, et.al. (2021). Gene deficiency or pharmacological inhibition of PDCD4-mediated FGR signaling protects against acute kidney injury. ［山东大学 rAAV9-Fgr-GFP & rAAV9-GFP 急性肾损伤］
● J Pharmacol Sci. (IF=3.337). Zhou J, et.al. (2021). Hyperoside ameliorates diabetic nephropathy induced by STZ via targeting the miR-499-5p/APC axis. ［南京中医药大学附属医院 AAV9-miR-499-5p & AAV9-APC 糖尿病肾病］
● EBIOMEDICINE. (IF=5.736). Liu, et.al. (2019). H19 promote calcium oxalate nephrocalcinosis-induced renal tubular epithelial cell injury via a ceRNA pathway.［华中科技大学同济医学院附属同济医院 AAV9-H19 肾钙质沉着症］
● Science Translational Medicine. (IF=16.304). Wang, et.al. (2018). Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway.［南方医科大学 AAV9-MIR-GFP-lnc-TSI 肾纤维化］
● Allergy (IF 12.4).Jia M, et.al. (2023). DEL-1, as an anti-neutrophil transepithelial migration molecule, inhibits airway neutrophilic inflammation in asthma.［南京医科大学第一附属医院 AAV6-DEL-1 鼻吸 支气管哮喘］
● Microbiology Spectrum（IF=9.043）.Zhang Z, et.al. (2023). Long Noncoding RNA AROD Inhibits Host Antiviral Innate Immunity via the miR-324-5p–CUEDC2 Axis.［浙江大学动物医学中心 AAV6-lnc-AROD & AAV6-NC 宿主先天防御］
● Cell Death & Disease. (IF=6.304). Zhang, et.al. (2019). circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA.［上海市第一人民医院 AAV6-circHIPK3 shRNA & scrambled shRNA 肺纤维化］
● Oncotarget. Tian, et.al. (2017). Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-β1/Smad3 signaling.［华中科技大学同济医学院公共卫生学院 AAV-Sirt6 特发性肺纤维化］
● Retrovirology. (IF=4.183). Wang, et.al. (2017). Genome modifcation of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection.［武汉大学基础医学院 AAV-SaCas9-CXCR4-gRNA HIV基因治疗］
● AGING CELL（IF=8）. Chen M, et.al. (2025). Senescent Macrophages Promote Age-Related Revascularization Impairment by Increasing Antiangiogenic VEGF-A165B Expression.［湖南省妇幼保健院 AAV9-Lyz2-shVegf-a165b、AAV9-Scramble 年龄相关的血管再生障碍］
● Cell Metab. (IF=27.287). Loft Anne, et.al. (2022). A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis.［德国慕尼黑赫尔姆霍茨中心&乌尔姆大学 AAV-LP1-Cre & AAV-LP1-Cremut 肝脏禁食与生酮反应］
● EBioMedicine. (IF=8.143). Song Haoyu, Xu Tong, Feng Xiaofei, et.al. (2020). Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2.［南方医科大学&暨南大学附属珠海医院 AAV2-Irg1-GFP & AAV2-Nrf2-GFP& AAV2-Keap1-GFP 腹主动脉瘤AAA］
● EBioMedicine. (IF=5.736). Lian, et.al. (2019). Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway. ［北京大学 AAV2-ADAM17-GFP & AAV2-GFP 主动脉夹层AD］
● Circulation Research. (IF=14.467). Fu, et.al. (2016). Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Defciency Drives Atherosclerotic Calcifcation. ［北京大学 AAV2-integrin β3 & AAV2-β-tail domain & AAV2-GFP 动脉粥样硬化AS］
● Leukemia (IF 11.4). Jiang J, et.al. (2023). Inserting EF1α-driven CD7-specific CAR at CD7 locus reduces fratricide and enhances tumor rejection.［浙大医学院 AAV-CD7 CAR CAR-T细胞疗法］
● CLINICAL CANCER RESEARCH（IF=13.801）.Zhang Y, et.al. (2023). Allogeneic CAR T Cells Targeting DLL3 Are Efficacious and Safe in Preclinical Models of Small Cell Lung Cancer.［Allogene公司 AAV-IL7 & AAV-IL15 小细胞肺癌］
● Mol Ther. (IF=12.910). Duan Y, et.al. (2022). Balancing activation and costimulation of CAR tunes signaling dynamics and enhances therapeutic potency. ［浙江大学医学院AAV-TRAC-1928z-WT & AAV-TRAC-1928z-1XX CAR-T细胞制备］
● Small Methods. (IF=15.367).Ruirui Jing，et.al.（2021）.Cas9-Cleavage Sequences in Size-Reduced Plasmids Enhance Nonviral Genome Targeting of CARs in Primary Human T Cells ［浙江大学AAV-TRAC-CAR-T ］
● Molecular Cell.(IF=17.970).Ling, et.al.(2021). Improving the efficiency of CRISPR-Cas12a-based genome editing with site-specific covalent Cas12a-crRNA conjugates.［北京大学AAV6-CD19 CAR CAR-T细胞制备］
● Molecular Therapy: Nucleic Acid（IF=10.183）.Iancu O, et.al. (2022). Multiplex HDR for Disease and Correction Modeling of SCID by CRISPR Genome Editing in Human HSPCs.［巴伊兰大学 AAV6病毒产品 严重联合免疫缺陷］
● Journal of Extracellular Vesicles. (IF 16). Huang et.al. (2023). Extracellular vesicle-packaged ILK from mesothelial cells promotes fibroblast activation in peritoneal fibrosis. [中山大学附属第三医院，AAV干扰载体、腹膜纤维化]
●CELL PROLIFERATION (IF 5.9).Zhang S, et.al. (2024). AAV-mediated gene therapy restores natural fertility and improves physical function in the Lhcgr-deficient mouse model of Leydig cell failure.［中山大学 AAV8-CAG-Lhcgr、AAVDJ-CAG-Lhcgr 雄性不育］
